Toni Kotnik is invited to give a lecture titled Computational Regeneration: Algorithmic Architecture for Ecological Engineering in the framework of the international seminar at the University of Seville. The seminar Towards S4 Architecture foregrounds a central question for contemporary architectural technology: how can quantitative performance frameworks align with ecological agency and territorial resilience? The objective of the meeting is to clarify how architectural intelligence can contribute to climate adaptation, energy transition and ecological enhancement through measurable yet systemic interventions.